USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

USC-OGP 2-DE database  Search by                Maps             Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal World-2DPAGE Repository Exclude local DBs has only effect if a remote interface is selected

Searching in 'USC-OGP 2-DE database' for entry matching: 1433B_HUMAN USC-OGP 2-DE database:  1433B_HUMAN 1433B_HUMAN General information about the entry View entry in simple text format Entry name 1433B_HUMAN Primary accession number P31946 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=14-3-3 protein beta/alpha; AltName: Full=Protein 1054; AltName: Full=Protein kinase C inhibitor protein 1; Short=KCIP-1; Contains: RecName: Full=14-3-3 protein beta/alpha, N-terminally processed;. Gene name Name=YWHAB Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_4-5 {PLATELET 4-5} Homo sapiens (Human)   map experimental info   PLATELET_4-5 MAP LOCATIONS: SPOT OGP-0168: pI=4.74; Mw=28392 SPOT OGP-0169: pI=4.72; Mw=28293 SPOT OGP-0172: pI=4.67; Mw=27703 SPOT OGP-0173: pI=4.70; Mw=27414 Cross-references UniProtKB/Swiss-Prot P31946; 1433B_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name 1433B_HUMAN Primary accession number P31946 Secondary accession number(s) A8K9K2 E1P616 Sequence was last modified on  January 23, 2007 (version 3) Annotations were last modified on  March 15, 2017 (version 195) Name and origin of the protein Description RecName: Full=14-3-3 protein beta/alpha; AltName: Full=Protein 1054; AltName: Full=Protein kinase C inhibitor protein 1; Short=KCIP-1; Contains: RecName: Full=14-3-3 protein beta/alpha, N-terminally processed; Gene name Name=YWHAB Encoded on Name=YWHAB Keywords 3D-structure; Acetylation; Alternative initiation; Complete proteome; Cytoplasm; Direct protein sequencing; Host-virus interaction; Nitration; Phosphoprotein; Polymorphism; Reference proteome. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL X57346; CAA40621.1; -; mRNA EMBL AK292717; BAF85406.1; -; mRNA EMBL AL008725; CAA15497.1; -; Genomic_DNA EMBL CH471077; EAW75893.1; -; Genomic_DNA EMBL CH471077; EAW75894.1; -; Genomic_DNA EMBL CH471077; EAW75896.1; -; Genomic_DNA EMBL BC001359; AAH01359.1; -; mRNA CCDS CCDS13339.1; -. [P31946-1]; . PIR S34755; S34755; . RefSeq NP_003395.1; NM_003404.4. [P31946-1]; . RefSeq NP_647539.1; NM_139323.3. [P31946-1]; . RefSeq XP_016883528.1; XM_017028039.1. [P31946-1]; . UniGene Hs.643544; -; . PDB 2BQ0; X-ray; 2.50 A; A/B=2-239 PDB 2C23; X-ray; 2.65 A; A=2-239 PDB 4DNK; X-ray; 2.20 A; A/B=1-246 PDBsum 2BQ0; -; . PDBsum 2C23; -; . PDBsum 4DNK; -; . ProteinModelPortal P31946; -; . SMR P31946; -; . BioGrid 113361; 339; . DIP DIP-743N; -; . IntAct P31946; 258; . MINT MINT-99570; -; . STRING 9606.ENSP00000300161; -; . iPTMnet P31946; -; . PhosphoSitePlus P31946; -; . SwissPalm P31946; -; . DMDM 1345590; -; . OGP P31946; -; . REPRODUCTION-2DPAGE IPI00216318; -; . EPD P31946; -; . PaxDb P31946; -; . PeptideAtlas P31946; -; . PRIDE P31946; -; . TopDownProteomics P31946-1; -. [P31946-1]; . TopDownProteomics P31946-2; -. [P31946-2]; . DNASU 7529; -; . Ensembl ENST00000353703; ENSP00000300161; ENSG00000166913. [P31946-1]; . Ensembl ENST00000372839; ENSP00000361930; ENSG00000166913. [P31946-1]; . GeneID 7529; -; . KEGG hsa:7529; -; . CTD 7529; -; . DisGeNET 7529; -; . GeneCards YWHAB; -; . HGNC HGNC:12849; YWHAB; . HPA CAB003759; -; . HPA HPA007925; -; . HPA HPA011212; -; . MIM 601289; gene; . neXtProt NX_P31946; -; . OpenTargets ENSG00000166913; -; . PharmGKB PA37438; -; . eggNOG KOG0841; Eukaryota; . eggNOG COG5040; LUCA; . GeneTree ENSGT00760000119116; -; . HOGENOM HOG000240379; -; . HOVERGEN HBG050423; -; . InParanoid P31946; -; . KO K16197; -; . OMA MGREYRE; -; . OrthoDB EOG091G0VKY; -; . PhylomeDB P31946; -; . TreeFam TF102003; -; . Reactome R-HSA-111447; Activation of BAD and translocation to mitochondria; . Reactome R-HSA-1445148; Translocation of GLUT4 to the plasma membrane; . Reactome R-HSA-165159; mTOR signalling; . Reactome R-HSA-166208; mTORC1-mediated signalling; . Reactome R-HSA-170968; Frs2-mediated activation; . Reactome R-HSA-170984; ARMS-mediated activation; . Reactome R-HSA-2028269; Signaling by Hippo; . Reactome R-HSA-392517; Rap1 signalling; . Reactome R-HSA-450385; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; . Reactome R-HSA-450513; Tristetraprolin (TTP; ZFP36) binds and destabilizes mRNA; . Reactome R-HSA-5625740; RHO GTPases activate PKNs; . Reactome R-HSA-5628897; TP53 Regulates Metabolic Genes; . Reactome R-HSA-5673000; RAF activation; . Reactome R-HSA-5674135; MAP2K and MAPK activation; . Reactome R-HSA-5675221; Negative regulation of MAPK pathway; . Reactome R-HSA-6802946; Signaling by moderate kinase activity BRAF mutants; . Reactome R-HSA-6802948; Signaling by high-kinase activity BRAF mutants; . Reactome R-HSA-6802949; Signaling by RAS mutants; . Reactome R-HSA-6802952; Signaling by BRAF and RAF fusions; . Reactome R-HSA-6802955; Paradoxical activation of RAF signaling by kinase inactive BRAF; . Reactome R-HSA-75035; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; . SignaLink P31946; -; . SIGNOR P31946; -; . ChiTaRS YWHAB; human; . EvolutionaryTrace P31946; -; . GeneWiki YWHAB; -; . GenomeRNAi 7529; -; . PRO PR:P31946; -; . Proteomes UP000005640; Chromosome 20; . Bgee ENSG00000166913; -; . CleanEx HS_YWHAB; -; . ExpressionAtlas P31946; baseline and differential; . Genevisible P31946; HS; . GO GO:0005737; C:cytoplasm; IDA:UniProtKB; . GO GO:0030659; C:cytoplasmic vesicle membrane; TAS:Reactome; . GO GO:0005829; C:cytosol; IDA:HPA; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0005925; C:focal adhesion; IDA:UniProtKB; . GO GO:0042470; C:melanosome; IEA:UniProtKB-SubCell; . GO GO:0016020; C:membrane; IDA:UniProtKB; . GO GO:0005739; C:mitochondrion; IEA:GOC; . GO GO:0005634; C:nucleus; IEA:Ensembl; . GO GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB; . GO GO:0043234; C:protein complex; IEA:Ensembl; . GO GO:0017053; C:transcriptional repressor complex; IEA:Ensembl; . GO GO:0045296; F:cadherin binding; IDA:BHF-UCL; . GO GO:0019899; F:enzyme binding; IPI:BHF-UCL; . GO GO:0042826; F:histone deacetylase binding; IPI:BHF-UCL; . GO GO:0051219; F:phosphoprotein binding; IPI:BHF-UCL; . GO GO:0050815; F:phosphoserine binding; IPI:BHF-UCL; . GO GO:0019904; F:protein domain specific binding; IPI:UniProtKB; . GO GO:0003714; F:transcription corepressor activity; IEA:Ensembl; . GO GO:0051220; P:cytoplasmic sequestering of protein; IDA:BHF-UCL; . GO GO:0035329; P:hippo signaling; TAS:Reactome; . GO GO:0000165; P:MAPK cascade; TAS:Reactome; . GO GO:0061024; P:membrane organization; TAS:Reactome; . GO GO:0045744; P:negative regulation of G-protein coupled receptor protein signaling pathway; IMP:UniProtKB; . GO GO:0035308; P:negative regulation of protein dephosphorylation; IDA:BHF-UCL; . GO GO:0045892; P:negative regulation of transcription; DNA-templated; IEA:Ensembl GO GO:0043085; P:positive regulation of catalytic activity; IDA:BHF-UCL; . GO GO:1900740; P:positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; TAS:Reactome; . GO GO:0051291; P:protein heterooligomerization; IEA:Ensembl; . GO GO:0006605; P:protein targeting; IEA:Ensembl; . GO GO:0043488; P:regulation of mRNA stability; TAS:Reactome; . GO GO:0016032; P:viral process; IEA:UniProtKB-KW; . Gene3D 1.20.190.20; -; 1; . InterPro IPR000308; 14-3-3; . InterPro IPR023409; 14-3-3_CS; . InterPro IPR023410; 14-3-3_domain; . PANTHER PTHR18860; PTHR18860; 1; . Pfam PF00244; 14-3-3; 1; . PIRSF PIRSF000868; 14-3-3; 1; . PRINTS PR00305; 1433ZETA; . SMART SM00101; 14_3_3; 1; . SUPFAM SSF48445; SSF48445; 1; . PROSITE PS00796; 1433_1; 1; . PROSITE PS00797; 1433_2; 1; .

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